Thursday, February 15, 2007

Molecular machine

The molecular machine that I researched was extremely interesting in many medically related aspects. The molecule is rotaxane. It consists of a dumbbell shaped conglomeration of molecules with a ring called a macrocycle that fits like a ring on a pencil in between the two "dumbbell" ends. Electron transfer stimulated by light input allows the ring (called a macrocycle) to shuttle up and down the axle between two electron accepting stations. Drug companies are hoping to synthesize a rotaxane with an axle that can be inserted into the membrane of a cell so that the ring may be used as a delivery system across the cell membrane. Need I explain how useful that would be if drugs were efficiently attached to the ring and could be transported directly inside the cell. I think this idea will eventually be helpful with research in several drugs/diseases. Rotaxanes are already efficiently synthesized according to templates in laboratories., and the project has been underway since the 1990's. This is fairly rapid progress.

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